Effect of Honey Administration on The Histopathology of The Duodenum of Wistar Rats as a Inhibition of The Toxic Effects of Borax (Sodium tetraborate)

Background: Borax can result in oxidative stress and cause the onset of gastrointestinal ulcerations that will dampen duodenal villi to become shorter even disappear. Cell damage due be prevented by administering antioxidants. Antioxidants inhibit chain reactions formation free radicals complementing existing electron deficiency. Honey is one natural ingredients rich antioxidants part thibbun Nabawi as inhibitors toxic effects borax. Objective : The purpose this study analyze effect honey administration on histopathological description submucosa epithelial mucosa wistar rats an inhibitor borax (Sodium tetraborate). Methods: This used true experimental method with Post Test Only Control Group Design using 25 mice which divided into five groups, namely K (negative control), P (positive M1 (borax dose 1), M2 2), M3 3). was conducted for 22 days then. Took organ all samples then made histological preparations HE staining. Observations were Olympus microscope see submucosal edema epithelium mucosa. Results: results found 26 mg / head day had influence picture In addition, 75 Kg BB provides a inhibitory duodenum best among other treatment groups. However, statistically there no Tetraborate) p˃0.05. Conclusion: Statistically it concluded histopathology